Current and Emergent Suicidal Ideation in Schizophrenia: Effect of Stressful Life Events and Genome-Wide Methylation
Year: 2020
Type: dissertation
Study design: Observational Study
Abstract: Suicide is a serious problem, especially in patients with schizophrenia. In order to prevent suicide, it is imperative to identify those with suicidal ideation and emergent suicidal ideation. We tested the effect of childhood trauma and recent stress on current and emergent suicidal ideation. Furthermore, we identified differentially methylated probes and regions associated with current suicidal ideation, as well as methylation changes in individual sites associated with emergent suicidal ideation. We found that an increase in total stress and health-related stress were significant predictors of emergent suicidal ideation. We also report the most significant positions and regions associated with current and emergent suicidal ideation. The anticipated outcomes of these studies were to improve the understanding about risk factors for suicidal ideation, and the identification of methylation markers to monitor for suicidal ideation in psychosis.
Source: TSpace (University of Toronto)
Author: Kevin Z. Wang
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: green
OpenAlex ID: W3158027767