Set-shifting-related basal ganglia deformation as a novel familial marker of obsessive–compulsive disorder
Year: 2021
Type: article
Study design: Observational Study
Abstract: The symptoms of obsessive-compulsive disorder (OCD) are suggestive of cognitive rigidity, and previous work identified impaired flexible responding on set-shifting tasks in such patients. The basal ganglia are central to habit learning and are thought to be abnormal in OCD, contributing to inflexible, rigid habitual patterns of behaviour. Here, we demonstrate that increased cognitive inflexibility, indexed by poor performance on the set-shifting task, correlated with putamen morphology, and that patients and their asymptomatic relatives had common curvature abnormalities within this same structure. The association between the structure of the putamen and the extradimensional errors was found to be significantly familial in OCD proband-relative pairs. The data implicate changes in basal ganglia structure linked to cognitive inflexibility as a familial marker of OCD. This may reflect a predisposing heightened propensity toward habitual response patterns and deficits in goal-directed planning.
DOI: 10.1192/bjp.2021.45
Institutions: Kyoto University, University of Cambridge, Nippon Foundation, Cambridgeshire and Peterborough NHS Foundation Trust, University College London, University of Hertfordshire, Hertfordshire Partnership University NHS Foundation Trust, University of Leicester, Southern Health NHS Foundation Trust, University of Southampton
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: hybrid
Estimated APC paid: $4,920
Funders: GlaxoSmithKline, Wellcome Trust, National Institute for Health and Care Research, University of Hertfordshire, Ministry of Education, Culture, Sports, Science and Technology, European College of Neuropsychopharmacology, H. Lundbeck A/S, Medical Research Council, Japan Society for the Promotion of Science
Awards: NIHR Senior Investigator Award, G3471132303, NIHR Senior Investigator Award, G4258145431, Refurbishment of the Herschel Smith building for Clinical Research in Cognitive Neuroscience at Cambridg University, G4989025076, Fronto-striatal systems in impulsive-compulsive disorders., G6252301425, G6868616705, Diagnostically cross-cutting intermediate phenotypes of impulsivity and compulsivity., Fronto-striatal systems in impulsive-compulsive disorders, G7592767236, G949648287
OpenAlex ID: W3158048796