Enantioselective Total Synthesis of the Archaeal Lipid Parallel GDGT‐0 (Isocaldarchaeol)**
Year: 2021
Type: article
Abstract: Archaeal glycerol dibiphytanyl glycerol tetraethers (GDGT) are some of the most unusual membrane lipids identified in nature. These amphiphiles are the major constituents of the membranes of numerous Archaea, some of which are extremophilic organisms. Due to their unique structures, there has been significant interest in studying both the biophysical properties and the biosynthesis of these molecules. However, these studies have thus far been hampered by limited access to chemically pure samples. Herein, we report a concise and stereoselective synthesis of the archaeal tetraether lipid parallel GDGT-0 and the synthesis and self-assembly of derivatives bearing different polar groups.
Institution: Stanford University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funders: National Science Foundation, National Aeronautics and Space Administration, Universität Basel, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, National Institutes of Health, Directorate for Mathematical and Physical Sciences, University of Illinois at Urbana-Champaign, National Institute of General Medical Sciences, Division of Electrical, Communications and Cyber Systems, Division of Chemistry, Division of Molecular and Cellular Biosciences
Awards: G1333989588, G1479047488, G1502681674, G2521557779, CAREER: Chemical Synthesis and Biophysical Study of Noncanonical Membrane Lipids, G3277470217, NNCI: Stanford University - SNSF, SNF, MAF, EMF, G4148033071, G5986892838, G6671297155, G6833933753, G6870985202, Organization and Dynamics in Photosynthetic Reaction Centers and Model Membrane Architectures, Biophysical studies of macromolecules and molecular assemblies
OpenAlex ID: W3158428524