Work

Utility of Multivalent Aptamers to Develop Nanoscale DNA Devices against Surface Receptors

Year: 2021

Type: review

Abstract: DNA nanotechnology is undergoing rapid progress in the assembly of functional devices with biological relevance. In particular, currently, the research attention is more focused on the application of nanodevices at the interface of chemistry and biology, on the cell membrane where protein receptors communicate with the extracellular environment. This review explores the use of multivalent nucleic acid ligands termed aptamers in the design of DNA-based nanodevices to probe cellular interactions followed by a perspective on the untapped utility of XNA and UBP nanotechnology in designing functional nanomaterials with broader structural space.

Source: ACS Omega

DOI: 10.1021/acsomega.1c01513

Authors: Lina Freage, Natalie Boykoff, Prabodhika Mallikaratchy

Institutions: Lehman College, City University of New York, The Graduate Center, CUNY

Language: English

Topic: Advanced biosensing and bioanalysis techniques

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $1,250

Funder: National Institute of General Medical Sciences