Dental Adhesive Systems Loaded with Antimicrobial Drug-silica-Co-assembled Particles for Interfacial Biodegradation and Recurrent Caries Reduction
Year: 2020
Type: dissertation
Abstract: Resin composite restorations fail prematurely mainly due to biodegradation and bacterial attack, leading to recurrent caries. It is hypothesized that 1) dental adhesives containing drug-silica-co-assembled-particles (DSPs) inhibit interfacial bacterial-biodegradation-markers (BBMs) and reduce interfacial demineralization and cavitation; 2) photothermal radiometry and luminescence (PTR-LUM) technology correlates positively with micro-computed-tomography (µCT) in recurrent caries detection. In vitro models based on simulated human salivary esterases and cariogenic bacteria to evaluate the effects of DSPs on interfacial biodegradation and recurrent caries development show long-term reduction in BBMs and interfacial demineralization and cavitation, suggesting that DSP-loaded dental adhesives are efficacious in reducing interfacial biodegradation and recurrent caries. PTR-LUM technology (the Canary System Numbers), was positively correlated to demineralization and cavitation measurements by µCT. Provision of antimicrobial-antidegradative properties to dental adhesives is a promising strategy to improve the longevity of resin composite restorations. Additionally, PTR-LUM technology may aid dental professionals in detecting recurrent caries, without radiation exposure.
Source: TSpace (University of Toronto)
Author: Kimberly Ngai
Language: English
Subfield: General Dentistry
Field: Dentistry
Domain: Health Sciences
Open Access status: green
Award: G3219723263
OpenAlex ID: W3158969415