Analysis of the familial aggregation of hypertension among patients with different types of kidney stone disease
Year: 1998
Type: dissertation
Study design: Observational Study
Abstract: Background. Past studies identified an association between kidney stone (KS) disease and hypertension (HTN). The aims of the present thesis are to determine whether there is a specific biochemical abnormality that is responsible for the association and whether the association has familial determinants. Methods. Two hundred and twelve KS patients (age 18-50 years) were classified into six diagnostic categories on the basis of their most prominent urinary metabolic abnormality, and were interviewed about the occurrence of HTN among their first-degree relatives. Familial aggregation of HTN was assessed by the comparison of the prevalence of strong family history (FHx) of HTN among the categories and by the comparison of prevalence of HTN among the fathers, mothers and siblings of the patients from the different diagnostic groups. Results. The prevalence of positive FHx of HTN was significantly higher in patients with hyperuricosuric KS disease (OR = 3.8 (1.22-11.66)), and the prevalence of HTN was significantly higher in siblings of the hyperuricosuric patients compared to the siblings of all other patients (OR = 3.8 (2.12-6.67)). The association was independent of the presence of HTN in the probands. Sub-group analysis among the hyperuricosuric patients revealed that it was those patients who had hypercalciuria in addition to hyperuricosuria that had positive FHx of HTN (OR = 9.0 (1.74-46.6)) and siblings of only these patients had significantly more HTN (OR = 5.5 (2.02-15.15)). These combined hyperuricosuric/hypercalciuric patients had higher serum levels of uric acid and higher urinary excretion of sodium and phosphorus besides the hyperuricosuria and hypercalciuria. Conclusion. That there is familial aggregation of HTN among KS patients who have high urinary excretion of uric acid especially when combined with hypercalciuria.
Author: András Tislér
Language: English
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3159595695