Work

HDAC2 links ubiquitination to tumor suppression in synovial sarcoma

Year: 2021

Type: editorial

Abstract: The function of histone deacetylase 2 (HDAC2) in transcriptional regulation and its role in oncogenesis have been well established. Here we discuss a transcription-independent HDAC2 pathway controlling cancer-related protein stability via the mouse double minute 2 homolog (MDM2) ubiquitin ligase. In synovial sarcoma, HDAC2 inactivation demonstrates significant therapeutic effect by degradation of the SS18-SSX driver oncoprotein.

Source: Molecular & Cellular Oncology

DOI: 10.1080/23723556.2021.1914291

Authors: Christina Cooley, Le Su

Institution: HudsonAlpha Institute for Biotechnology

Language: English

Topic: Histone Deacetylase Inhibitors Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,590

OpenAlex ID: W3159602776

Cites: 53

Cited by: 10

Related to: 10