Embryonic Stem Cell Pluripotency: MgFe‐LDH Nanoparticles: A Promising Leukemia Inhibitory Factor Replacement for Self‐Renewal and Pluripotency Maintenance in Cultured Mouse Embryonic Stem Cells (Adv. Sci. 9/2021)
Year: 2021
Type: article
Abstract: In article number 2003535, Rongrong Zhu and co-workers report the role of MgFe-LDH nanoparticles as a promising LIF replacement in maintaining mESCs self-renewal and pluripotency. Combined transcriptomic and proteomic analysis reveals that MgFe-LDH could activate LIFR regulating signaling pathways, while the extra Fe2+ provided by MgFe-LDH also enhances TET1/2 abundance related to DNA demethylation. This biocompatible MgFe-LDH nanoparticle favors economical and efficient replacement for LIF in large-scale expansion of ESCs.
Source: Advanced Science
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,000
OpenAlex ID: W3159636114