Work

SIK2 orchestrates actin-dependent host response upon Salmonella infection

Year: 2021

Type: article

Abstract: Significance Through conducting quantitative proteomics upon Salmonella infection, we identified a SIK2 signaling network, implementing the kinase into a so far concealed biological function. Our data exposed SIK2 as a central orchestrator of an actin regulatory network, coordinating the stability of Salmonella -containing vacuole (SCV) and cellular actin assembly, in order to limit the acute phase of the infection. Most strikingly, SIK2 is not exclusively acting locally on actin assembly associated with the SCV but impacts the actin cytoskeleton architecture in its entirety upon Salmonella infection. Our work provides a mechanistic framework for how the actin cytoskeleton is regulated and how it helps to control an acute Salmonella infection.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.2024144118

Authors: Marcel Hahn, Adriana Covarrubias-Pinto, Lina Herhaus, Shankha Satpathy, Kevin Klann, Keith B. Boyle, Christian Münch, Krishnaraj Rajalingam, Felix Randow, Chunaram Choudhary, Ivan Dikic

Institutions: Goethe University Frankfurt, University of Copenhagen, Novo Nordisk Foundation, MRC Laboratory of Molecular Biology, Medical Research Council, University Medical Center of the Johannes Gutenberg University Mainz

Language: English

Topic: Salmonella and Campylobacter epidemiology

Subfield: Food Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: European Commission, Deutsche Forschungsgemeinschaft, Novo Nordisk, Novo Nordisk Fonden, H2020 European Research Council

Awards: G1076064052, Dissecting and targeting ubiquitin networks in the course of bacterial infections, G3541515630, G4282887365, G434337789, G5290293035, SFB 1177: Molekulare und funktionale Charakterisierung der selektiven Autophagie, SPP 1580: Intracellular compartments as places of pathogenhostinteractions

OpenAlex ID: W3159727331

FWCI: 1.292

Cites: 60

Cited by: 13

Related to: 10