Biocompatibility of Poly-3-amino-4-methoxybenzoic Acid-Gelatin Hydrogel as a Novel Therapy for Cardiac Arrhythmia
Year: 2020
Type: dissertation
Abstract: After myocardial infarction, the nonconductive nature of fibrotic tissue results in ventricular dysfunction by electrically uncoupling the remaining viable cardiomyocytes in the scar region. The uneven conductive properties between normal myocardium and scar tissue may result in arrhythmias leading to sudden cardiac death or heart failure. Our laboratory has synthesized a conductive biomaterial polymer, poly-3-amino-4-methoxybenzoic acid-gelatin (PAMB-G), that can re-synchronize myocardial contraction in vivo. To evaluate the potential of PAMB-G for clinical application, its toxicity must be assessed. I found that PAMB-G was non-cytotoxic to cardiomyocytes and stem cells. The therapeutic dose of PAMB-G was below biomaterial’s no-observed-adverse-effect-level. The infarct rat hearts injected with PAMB-G have similar toxicity parameters (body weight, organ-brain ratios, hematologic parameters, serum parameters, and histology) compared to those injected with saline up to 3 months. PAMB-G did not result in any reproductive toxicity. In conclusion, PAMB-G is a non-toxic conductive biomaterial that should proceed to clinical evaluation for patients with desynchronized contraction.
Source: TSpace (University of Toronto)
Author: Fu, Anne
Institution: University of Toronto
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3159961973