Comparative Efficacy of Electronic Cigarettes versus Nicotine Patches as a Short-term Replacement for Tobacco Cigarette Smoking: A Cross-over Trial
Year: 2020
Type: dissertation
Abstract: Electronic cigarettes (e-cigarettes) have been reported to decrease craving, withdrawal, and cigarette consumption. Moreover, some research suggests smokers using an e-cigarette are as or more likely to achieve abstinence than smokers using nicotine replacement therapy. Using a novel, within-subjects, partial Latin square design, we investigated the efficacy of a second-generation nicotine e-cigarette and placebo e-cigarette against the nicotine patch in the short-term replacement of tobacco cigarette smoking. 25 participants have completed the study. Mean days of complete smoking replacement and percent cigarettes replaced was similar between the nicotine e-cigarette (1.84, 72.2%), placebo e-cigarette (1.48, 67.9%), and nicotine patch (1.52, 73.1%). Craving score was similar among products whereas withdrawal score was significantly lower with placebo e-cigarette use over nicotine e-cigarette and nicotine patch use. These findings demonstrate the efficacy of a second-generation e-cigarette, with and without nicotine, in short-term smoking replacement and presents evidence supporting its use over the nicotine patch.
Source: TSpace (University of Toronto)
Author: Ernesto Hernandez Ramos
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3160073259