Work

Leptin increases GABAergic synaptogenesis through the Rho guanine exchange factor β-PIX in developing hippocampal neurons

Year: 2021

Type: article

Abstract: in the leptin receptor and the SH3 domain of β-PIX are crucial for this interaction, which was required for the developmental increase in GABAergic synaptogenesis. Our results suggest a mechanism by which leptin promotes GABAergic synaptogenesis in hippocampal neurons and reveal further complexity in leptin receptor signaling and its interactome.

Source: Science Signaling

DOI: 10.1126/scisignal.abe4111

Authors: Gulcan Semra Sahin, Jose Luis Rodriguez-Llamas, Crystal Dillon, Igor Medina, Suzanne M. Appleyard, Jean-Luc Gaiarsa, Gary A. Wayman

Institutions: Washington State University, Inserm, Aix-Marseille Université, Institut de Neurobiologie de la Méditerranée

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Mental Health, National Institute of Diabetes and Digestive and Kidney Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: Leptin regulation of GABAergic synaptogenesis and excitation-inhibition balance during development: effects of maternal obesity, Integration of Peripheral and Central Appetite Signals by Brainstem Neurons, Control of Dendritic and Synaptic Development by Extracellular Cues

OpenAlex ID: W3160144011

FWCI: 0.903

Cites: 78

Cited by: 12

Related to: 10