Effect of Nuts on Markers of Cancer and Coronary Heart Disease Risk in Type 2 Diabetes: A Dose Response Study
Year: 2014
Type: dissertation
Abstract: Nuts have been shown to reduce coronary heart disease (CHD) risk and possibly cancer development. However, the mechanisms are not clear, and the small but consistent LDL-C reduction does not explain the 18-51% CHD risk reduction observed. Therefore, the effect of nuts was assessed on serum fatty acids, measures of oxidative stress, and prostate cancer (LNCaP) cell growth as part of a secondary analysis of a 12-week feeding trial (100 participants) in type 2 diabetes to explore possible mechanisms. Nuts increased serum oleic acid and monounsaturated fatty acids in the phospholipid fraction and this change related inversely to Framingham Risk Score. However, no associations were seen with markers of oxidative stress or in vitro LNCaP cell growth. It is concluded that intake of monounsaturated fat associated with the Mediterranean diet reduces CHD risk, but the beneficial effect of nuts on CHD and possible effects on cancer remain to be explained mechanistically.
Source: TSpace (University of Toronto)
Author: Stephanie Nishi
Language: English
Topic: Nuts composition and effects
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: green
Funder: University of Toronto
OpenAlex ID: W3161167499