Work

Childhood adversity, prenatal depression, and maternal inflammation across pregnancy

Year: 2021

Type: article

Abstract: Background: To examine whether change in neutrophil-lymphocyte ratio, a marker of systemic inflammation, differs by childhood adversity and prenatal depression. Methods: Prenatal complete blood count data were used to calculate neutrophil-lymphocyte ratio in first and third trimesters. The Adverse Childhood Experiences scale measured childhood adversity, and the Patient Health Questionnaire-9 measured depression. This is a secondary analysis of a study of predictors of risk for sleep-disordered breathing. Results: = 7), 61% identified as white, and 28% identified as Hispanic. Women who reported childhood sexual abuse history displayed greater increase in neutrophil-lymphocyte ratio over pregnancy relative to women without childhood sexual abuse. Change in neutrophil-lymphocyte ratio across pregnancy did not differ by prenatal depression. Conclusion: Experiences of sexual abuse in childhood may impact markers of systemic inflammation in pregnancy.

Source: Obstetric Medicine

DOI: 10.1177/1753495x211011910

Authors: Margaret H Bublitz, Taylor Freeburg, Meghan Sharp, Myriam Salameh, Ghada Bourjeily

Institutions: Brown University, Miriam Hospital

Language: English

Topic: Maternal Mental Health During Pregnancy and Postpartum

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development