Early Determination of Prognosis in Neonatal Moderate or Severe Hypoxic-Ischemic Encephalopathy
Year: 2021
Type: article
Abstract: BACKGROUND AND OBJECTIVES: Early determination of prognosis is important in neonates with hypoxic-ischemic encephalopathy (HIE). Our objective was to test scoring systems developed earlier (original scoring system) and develop new prognostic models. METHODS: Secondary analysis of data from the multicenter randomized controlled trial of longer, deeper, or usual care cooling in neonatal HIE (NCT01192776) that enrolled 364 neonates diagnosed with moderate or severe HIE. The primary outcome was death or moderate or severe disability at 18 to 22 months, and secondary outcome was death during initial hospitalization. Testing of early neurologic clinical examination (<6 hours of age) and the original scoring system for prognostic ability was done, followed by development of new scoring systems and classification and regression tree (CART) models by using early clinical variables (<6 hours of age). RESULTS: For death or disability, the original scoring system correctly classified 75% (95% confidence interval: 69%-81%), whereas the new scoring system correctly classified 78% (73%-82%), and the CART model correctly classified 76% (72%-81%). Early neurologic clinical examination also had a correct classification rate of 76% (71%-80%). Depth and duration of cooling did not affect prediction. Only a few components of the early neurologic examination were associated with poor outcome. For death, the original scoring system correctly classified 72% (66%-77%), the new scoring system 68% (63%-72%), the new CART model 87% (83%-90%), and early neurologic evaluation 81% (77%-85%). CONCLUSIONS: The 3 models (scoring system, CART, and early neurologic evaluation) were comparable in predicting death or disability. For in-hospital death, CART models were superior to scoring systems and early neurologic examination.
Source: PEDIATRICS
Institutions: University of Alabama at Birmingham, UAB Medicine, Wayne State University, Women & Infants Hospital of Rhode Island, RTI International, Duke University, Children's Hospital of Philadelphia, George Mason University, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: NICHD Cooperative Multicenter Neonatal Research Network, The Children's Mercy-Truman-UMKC Center: A New Addition for the Next 5 Years, Clinical Center for NICHD/Neonatal Research Network, NICHD Cooperative Multicenter Neonatal Research Network, Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal Research Network, NICHD Cooperative Multicenter Neonatal Research Network, Cooperative Multicenter Neonatal Research Network, NICHD Cooperative Multicenter Neonatal Research Network, Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal Research Network, Multicenter Network of Neonatal Intensive Care Units, Cooperative Multicenter Neonatal Research Network - UAB, NICHD Cooperative Multicenter Neonatal Research Network, Multicenter Network of Neonatal Intensive Care Units, Neonatal Research Network Data Coordinating Center (DCC), Cooperative Multicenter Network of Neontal Intensive Care Units, NICHD Cooperative Multicenter Neonatal Research Network, NICHD Cooperative Multicenter Neonatal Research Network, Duke CTSI, NICHD Neonatal Research Network, Multicenter Network of Neonatal Intensive Care Units-University of Texas at Houston (UT Houston) Clinical Center, Rochester-Buffalo Neonatal Research Group, Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal Research Network, NICHD Cooperative Multicenter Neonatal Research Network - Utah Center, Neonatal Research Network Data Coordinating Center (DCC) 2023-2028, NICHD Cooperative Multicenter Neonatal Research Network - UCLA
OpenAlex ID: W3161390102