Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts
Year: 2016
Type: article
Abstract: Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1-19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.
Source: Scientific Reports
DOI: 10.1038/srep28496
Authors: Aline Jelenkovic, Reijo Sund, Yoon-Mi Hur, Yoshie Yokoyama, Jacob v. B. Hjelmborg, Sören Möller, Chika Honda, Patrik K. E. Magnusson, Nancy L. Pedersen, Syuichi Ooki, Sari Aaltonen, Maria A. Stazi, Corrado Fagnani, Cristina D’Ippolito, Duarte L. Freitas, José Antonio Maia, Fuling Ji, Feng Ning, Zengchang Pang, Esther Rebato, Andreas Busjahn, Christian Kandler, Kimberly J. Saudino, Kerry L. Jang, Wendy Cozen, Amie E. Hwang, Thomas M. Mack, Wenjing Gao, Canqing Yu, Liming Li, Robin P. Corley, Brooke M. Huibregtse, Catherine A. Derom, Robert F. Vlietinck, Ruth J. F. Loos, Kauko Heikkilä, Jane Wardle, Clare H. Llewellyn, Abigail Fisher, Tom A. McAdams, Thalia C. Eley, Alice M. Gregory, Mingguang He, Xiaohu Ding, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Adam D. Tarnoki, David L. Tarnoki, Ariel Knafo-Noam, David Mankuta, Lior Abramson, S. Alexandra Burt, Kelly L. Klump, Judy L. Silberg, Lindon J. Eaves, Hermine H. Maes, Robert F. Krueger, Matt McGue, Shandell Pahlen, Margaret Gatz, David A. Butler, Meike Bartels, Toos C. E. M. van Beijsterveldt, Jeffrey M. Craig, Richard Saffery, Lise Dubois, Michel Boivin, Mara Brendgen, Ginette Dionne, Frank Vitaro, Nicholas G. Martin, Sarah E. Medland, Grant W. Montgomery, Gary E. Swan, Ruth Krasnow, Per Tynelius, Paul Lichtenstein, Claire M. A. Haworth, Robert Plomin, Gombojav Bayasgalan, Danshiitsoodol Narandalai, K. Paige Harden, Elliot M. Tucker-Drob, Timothy Spector, Massimo Mangino, Genevieve Lachance, Laura A. Baker, Catherine Tuvblad, Glen E. Duncan, Dedra Buchwald, Gonneke Willemsen, Axel Skytthe, Kirsten O. Kyvik, Kaare Christensen, Sevgi Y. Öncel, Fazil Aliev, Finn Rasmussen, Jack H. Goldberg, Thorkild I. A. Sørensen, Dorret I. Boomsma, Jaakko Kaprio, Karri Silventoinen
Institutions: University of Helsinki, University of the Basque Country, Mokpo National University, Osaka City University, University of Southern Denmark, The University of Osaka, Karolinska Institutet, Ishikawa Prefectural Nursing University, Istituto Superiore di Sanità, Universidade da Madeira, Universidade do Porto, Qingdao Municipal Center for Disease Control and Prevention, Bielefeld University, Boston University, University of British Columbia, University of Southern California, USC Norris Comprehensive Cancer Center, Peking University, University of Colorado Boulder, Universitair Ziekenhuis Leuven, Ghent University Hospital, Icahn School of Medicine at Mount Sinai, University College London, King's College London, Goldsmiths University of London, Sun Yat-sen University, The University of Melbourne, Centre for Eye Research Australia, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Statens Serum Institut, Bandim Health Project, Odense University Hospital, Semmelweis University, Hebrew University of Jerusalem, Hadassah Medical Center, Michigan State University, Virginia Commonwealth University, VCU Massey Comprehensive Cancer Center, University of Minnesota, National Academy of Medicine, National Academy of Sciences, Vrije Universiteit Amsterdam, Royal Children's Hospital, Murdoch Children's Research Institute, University of Ottawa, National Research Tomsk State University, Université Laval, Université du Québec à Montréal, Université de Montréal, QIMR Berghofer Medical Research Institute, Stanford Medicine, Stanford University, SRI International, University of Bristol, MRC Integrative Epidemiology Unit, Hiroshima University, The University of Texas at Austin, Örebro University, Washington State University Spokane, Washington State University, Kırıkkale University, University of Washington, University of Copenhagen, Novo Nordisk Foundation, Frederiksberg Hospital, Bispebjerg Hospital, Novo Nordisk Foundation Center for Basic Metabolic Research, Finnish Institute for Health and Welfare, Institute for Molecular Medicine Finland
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,690
Funders: William T. Grant Foundation, Tobacco-Related Disease Research Program, University of Southern California, Velux Stiftung, Washington State University, Michigan State University, University of Washington, Bonnie Babes Foundation, Wellcome Trust, Michigan State University Foundation, Kırıkkale Üniversitesi, Cancer Research UK, National Institute for Health and Care Research, Leverhulme Trust, King's College London, National Research Foundation, National Natural Science Foundation of China, ZonMw, Vrije Universiteit Amsterdam, Academy of Finland, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, National Research Foundation of Korea, Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, State Government of Victoria, Vlaamse regering, National Institutes of Health, Directorate for Biological Sciences, College of Engineering, Michigan State University, Forsknings- og Innovationsstyrelsen, Medical Research Council, Biotechnology and Biological Sciences Research Council, Economic and Social Research Council, National Health and Medical Research Council, Japan Society for the Promotion of Science, Danish Agency for Science and Higher Education, Fundação para a Ciência e a Tecnologia, National Institute on Alcohol Abuse and Alcoholism, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute on Drug Abuse, National Institute of Environmental Health Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, FP7 Ideas: European Research Council, FP7 Health
Awards: G1075849409, G1093531541, G1099494159, G1108774313, G1110999434, G1140657321, G119964413, G1311351439, G1393617006, G1409398652, G1420010978, The Effects of Estradiol on Genetic Risk for Disordered Eating During Puberty, G1520690021, G1569838456, G1698415274, G178382592, G1795780048, Building a Unique National Community Based Twin Repository, G2055575246, G2189011847, G2238725043, G2330461282, USE &ABUSE OF ALCOHOL--A BEHAVIOR-GENETICS PERSPECTIVE, G2382756871, G242423306, G2433343305, Hormones in Sex-different Developmental Psychopathology, A twin study of ovarian hormones and disordered eating, G2473961061, G2496263360, G2512784349, G2563833389, G2684863890, G2761558319, G279455444, G2861369480, G289688219, G2899750288, Chronic stress and executive function in children: a neuroimaging study of twins, リンパ球の膜抗原と膜レセプター, G2973790809, G3077543175, Oldest-old Mortality - Demographic Models and Analysis, G3127488624, Developmental Change in Temperament in Preschoolers: Implications and Etiology, G31757887, G3250631134, G326470056, G3333874486, Research Training - Genetics of Substance Abuse, G3368366672, G3456816189, G357049385, Gene-environment Interactions in Childhood Conduct Problems, G3757293254, G3794989908, G3964375220, G3969217981, G4050873927, Adolescent Alcohol Abuse: A Twin-Study Perspective, Determinants of Behavioral Development, G423326604, Center on Antisocial Drug Dependence: The Genetics of HIV Risk Behaviors, G4330096051, G4367295956, G4374445680, G4381011041, International research project on physical growth and long-term prognosis in Twins and multiple births, G4446757277, G4460629988, G4536776401, G4599390081, G4682662344, G4757721458, Origins of learning difficulties and behaviour problems: from behavioural genetics to behavioural genomics., G4924186877, スピネル型鉄酸化物の電極特性, From the Child's Genes to Parental Environment and Back to the Child: Gene-environment Correlations in Early Social Development, G5349006154, G5468713758, G5471839915, Development of Externalizing Behavior Problems: Gene-Environment Interplay, G5612962370, Integrating contextual, proximal, and individual risks for child conduct problems, G5669758638, G5732418131, BEHAVIORAL PRECURSORS OF ALCOHOLISM--TWIN FAMILY STUDIES, G597584310, G6030094504, DNA methylation differences between identical twins, G6229538190, G626177176, Influências genéticas e de envolvimento na actividade física, aptidão e saúde: o estudo de famílias da Madeira, G634521393, G6367764764, G6412048503, G6663973959, G6728033037, G7003971911, G70080636, 水生丝孢菌趋同进化的分子机制, G7031888331, G7123559464, G7245677640, G7365436527, Adolescent Alcohol Abuse: A Twin-Study Perspective, G7583787834, G7689853932, 2-フッ化ピリジニウム塩を用いるテルペンアルコールの環化反応の研究, G7780068114, G7787549875, Genetic Influences on Activity Level in Early Childhood, G7914056507, G7956052275, G8034765632, The Greatest Generation: The NAS-NRC WWII Twin Registry as a Scientific Resource, Familial Transmission of Eating Pathology &Sex Hormones, G822877548, Predicting birth and early life outcomes, G841499813, G8467350387, G858414785, G8642381730, G8898866349, How do we change from conception to birth?, Population Research Center, G9000309104, Testing Gene-Testosterone Interplay in Adolescent Alcohol Use, G961365294
OpenAlex ID: W2471943374