Alveolar Bone Marrow Gli1+ Stem Cells Support Implant Osseointegration
Year: 2021
Type: article
Abstract: Osseointegration is the key issue for implant success. The in vivo properties of cell populations driving the osseointegration process have remained largely unknown. In the current study, using tissue clearing–based 3-dimensional imaging and transgenic mouse model-based lineage tracing methods, we identified Gli1+ cells within alveolar bone marrow and their progeny as the cell population participating in extraction socket healing and implant osseointegration. These Gli1 + cells are surrounding blood vessels and do not express lineage differentiation markers. After tooth extraction and delayed placement of a dental implant, Gli1 + cells were activated into proliferation, and their descendants contributed significantly to new bone formation. Ablation of Gli1 + cells severely compromised the healing and osseointegration processes. Blockage of canonical Wnt signaling resulted in impaired recruitment of Gli1 + cells and compromised bone healing surrounding implants. Collectively, these findings demonstrate that Gli1 + cells surrounding alveolar bone marrow vasculature are stem cells supporting dental implant osseointegration. Canonical Wnt signal plays critical roles in regulating Gli1 + stem cells.
Source: Journal of Dental Research
Authors: Y. Yi, W. Stenberg, W. Luo, J.Q. Feng, H. Zhao
Language: English
Subfield: Oral Surgery
Field: Dentistry
Domain: Health Sciences
Open Access status: green
Awards: The tendon cell is a robust alternative lineage for bone repair upon trauma or inflammation, Regulating niche of periodontium mesenchymal stem cells under the physiological condition, Utilizing tissue clearing based 3-D imaging to quantitatively study neural regulation of craniofacial mesenchymal stem cells
OpenAlex ID: W3163138585