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The Impact of Insulin Resistance on Cardiovascular Control During Exercise in Diabetes

Year: 2021

Type: article

Abstract: Patients with diabetes display heightened blood pressure response to exercise, but the underlying mechanism remains to be elucidated. There is no direct evidence that insulin resistance (hyperinsulinemia or hyperglycemia) impacts neural cardiovascular control during exercise. We propose a novel paradigm in which hyperinsulinemia or hyperglycemia significantly influences neural regulatory pathways controlling the circulation during exercise in diabetes.

Source: Exercise and Sport Sciences Reviews

DOI: 10.1249/jes.0000000000000259

Authors: Masaki Mizuno, Norio Hotta, Rie Ishizawa, Han-Kyul Kim, Gary Iwamoto, Wanpen Vongpatanasin, Jere H. Mitchell, Scott A. Smith

Institutions: The University of Texas Southwestern Medical Center, Chubu University

Language: English

Topic: Cardiovascular and exercise physiology

Subfield: Complementary and alternative medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Japan Society for the Promotion of Science, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: TARGETING INSULIN RESISTANCE TO IMPROVE ABNORMAL CARDIOVASCULAR CONTROL IN DIABETES, Mechanisms of abnormal blood pressure response to exercise in the brain insulin resistance observed in Alzheimer's disease and novel physiological actions of insulin, Preventing Hypertension and Sympathetic Overactivation by Targeting Phosphate, UT Southwestern O'Brien Kidney Research Core Center

OpenAlex ID: W3163787056

FWCI: 2.248

Cites: 142

Cited by: 15

Related to: 10