Work

Lung Transplantation and the Era of the Sensitized Patient

Year: 2021

Type: article

Abstract: Long term outcomes in lung transplant are limited by the development of chronic lung allograft dysfunction (CLAD). Within the past several decades, antibody-mediated rejection (AMR) has been recognized as a risk factor for CLAD. The presence of HLA antibodies in lung transplant candidates, "sensitized patients" may predispose patients to AMR, CLAD, and higher mortality after transplant. This review will discuss issues surrounding the sensitized patient, including mechanisms of sensitization, implications within lung transplant, and management strategies.

Source: Frontiers in Immunology

DOI: 10.3389/fimmu.2021.689420

Authors: Katherine A. Young, Hakim A. Ali, Kristi J. Beermann, John M. Reynolds, Laurie D. Snyder

Institutions: Duke University, Duke Medical Center, Duke University Hospital

Language: English

Topic: Transplantation: Methods and Outcomes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,950