Work

Daratumumab in Patients With Bortezomib-Refractory Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits

Year: 2021

Type: article

Abstract: Monoclonal gammopathy describes the presence of a monoclonal immunoglobulin (mIg) in the serum or urine that is secreted by a clonal population of the B-cell lineage.1–3 The clonal population can cause organ damage via a variety of mechanisms such as tumor burden, immunomodulation, and mIg deposition. The term monoclonal gammopathy of renal significance is used to describe kidney involvement that is not due to tumor burden. Patients with monoclonal gammopathy of renal significance often develop progressive renal dysfunction that can progress to end-stage kidney disease, and it commonly recurs after kidney transplantation.

Source: Kidney International Reports

DOI: 10.1016/j.ekir.2021.05.008