In Vivo Platelet Detection Using a Glycoprotein IIb/IIIa-Targeted Near-Infrared Fluorescence Imaging Probe
Year: 2021
Type: article
Abstract: Platelets play a prominent role in multiple diseases, in particular arterial and venous thrombosis and also in atherosclerosis and cancer. To advance the in vivo study of the biological activity of this cell type from a basic experimental focus to a clinical focus, new translatable platelet-specific molecular imaging agents are required. Herein, we report the development of a near-infrared fluorescence probe based upon tirofiban, a clinically approved small-molecule glycoprotein IIb/IIIa inhibitor (GPIIb/IIIa). Through in vitro experiments with human platelets and in vivo ones in a murine model of deep-vein thrombosis, we demonstrate the avidity of the generated probe for activated platelets, with the added benefit of a short blood half-life, thereby enabling rapid in vivo visualization within the vasculature.
Source: ACS Sensors
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Novel PET/CT and Treatment Strategies to reduce PTS following DVT, Targeting Cell-specific Functions of the Rho Kinase Pathway in Pulmonary Fibrosis, G3162065745, The Monocyte/Macrophage Role in Experimental Deep Vein Thrombosis Resolution and Vein Wall Injury, Intravascular NIRF-IVUS imaging of inflammation-guided arterial therapy, Targeted inhibition of fibrosis for the prevention of heart failure, NIRF-OFDI of Inflammation in Atheroma Progression and Stent Complications
OpenAlex ID: W3164168235