Work

Author response: Downregulation of glial genes involved in synaptic function mitigates Huntington's disease pathogenesis

Year: 2021

Type: peer-review

Abstract: Cross-species transcriptomic analysis and high-throughput behavioral assays in a Drosophila model of Huntington's disease show that downregulation of glial genes involved in synaptic function compensates for disease-related excitotoxicity.

Source: eLife

DOI: 10.7554/elife.64564.sa2

Authors: Tarik Seref Onur, Andrew Laitman, He Zhao, Ryan Keyho, Hyemin Kim, Jennifer Wang, Megan Mair, Huilan Wang, Lifang Li, Alma Perez, Maria de Haro, Ying-Wooi Wan, Genevera Allen, Boxun Lu, Ismael Al-Ramahi, Zhandong Liu, Juan Botas

Institutions: Baylor College of Medicine, Texas Children's Hospital, Fudan University, State Key Laboratory of Medical Neurobiology, Rice University

Language: English

Topic: Genetic Neurodegenerative Diseases

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500

OpenAlex ID: W3164292875

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