Year: 2021
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Blood type has been associated with the risk of gastric cancer, but few studies have examined the association with esophageal squamous cell carcinoma (ESCC). METHODS: We conducted a case-control study using genotyping data of Chinese individuals, including cases of 2022 ESCC, 1189 gastric cardia adenocarcinoma, 1161 gastric noncardia adenocarcinoma, and 2696 controls. Genetic blood type was imputed using three single nucleotide polymorphisms. We used logistic regression to examine the association between blood type and the risk of each cancer. RESULTS: Compared to blood type O, the risk of ESCC was significantly elevated for blood type B and AB, with the highest risk for type AB (OR, 95%CI: 1.34, 1.07-1.67). Analysis of genotype suggested that the association of ESCC was from carrying the B allele. Similarly, blood type was significantly associated with gastric noncardia adenocarcinoma (P < 0.001) with risk significantly elevated in type A (1.37, 1.14-1.65) and AB (1.44, 1.10-1.89) compared to type O. Blood type was not associated with gastric cardia adenocarcinoma (P = 0.13). CONCLUSIONS: This study provides novel insights into the association between blood type and the risk of ESCC and restricted previously observed association to only gastric noncardia cancer, providing important evidence to clarify the pattern of association and suggesting mechanisms of action.
Source: BMC Cancer
Institutions: National Institutes of Health, Division of Cancer Epidemiology and Genetics, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, University of Pittsburgh, UPMC Hillman Cancer Center, University of Pittsburgh Medical Center, National University of Singapore, SingHealth Duke-NUS Academic Medical Centre, Duke-NUS Medical School, Chinese Academy of Medical Sciences & Peking Union Medical College
Language: English
Topic: Blood groups and transfusion
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,570
Funders: Vanderbilt University, Vanderbilt-Ingram Cancer Center, University of Pittsburgh, Vanderbilt University Medical Center, Duke-NUS Medical School, National University of Singapore, Chinese Academy of Medical Sciences, Peking Union Medical College, National Institutes of Health, Graduate School of Public Health, University of Pittsburgh, National Cancer Institute
Awards: ENVIRONMENTAL EXPOSURES IN CANCER ETIOLOGY, Prospective studies of cancer etiology and prevention in Shanghai and Singapore, THE SINGAPORE COHORT STUDY OF DIET AND CANCER, G4014730521, Cohort Study of Cancer-Inhibitory Dietary Factors in Men, Cancer epidemiology cohorts in Shanghai and Singapore , Shanghai Womens Health Study, COHORT STUDY OF DIET AND NASOPHYARYNGEAL CANCER, G92400254
OpenAlex ID: W3164363368