Work

Autophagy and ALS: mechanistic insights and therapeutic implications

Year: 2021

Type: review

Abstract: : ALS: amyotrophic lateral sclerosis; Atg: autophagy-related; CHMP2B: charged multivesicular body protein 2B; DPR: dipeptide repeat; FTD: frontotemporal dementia; iPSC: induced pluripotent stem cell; LIR: LC3-interacting region; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MTOR: mechanistic target of rapamycin kinase; PINK1: PTEN induced kinase 1; RNP: ribonuclear protein; sALS: sporadic ALS; SPHK1: sphingosine kinase 1; TARDBP/TDP-43: TAR DNA binding protein; TBK1: TANK-binding kinase 1; TFEB: transcription factor EB; ULK: unc-51 like autophagy activating kinase; UPR: unfolded protein response; UPS: ubiquitin-proteasome system; VCP: valosin containing protein.

Source: Autophagy

DOI: 10.1080/15548627.2021.1926656

Authors: Jason P. Chua, Hortense De Calbiac, Edor Kabashi, Sami J. Barmada

Institutions: University of Michigan, Hôpital Necker-Enfants Malades, Inserm, Institut des Maladies Génétiques Imagine, Université Paris Descartes

Language: English

Topic: Amyotrophic Lateral Sclerosis Research

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institute on Aging, National Institute of Neurological Disorders and Stroke