Work

Quantitative modeling to understand cell signaling in the tumor microenvironment

Year: 2021

Type: review

Abstract: Tumor cells play a central role in multiple processes associated with cancer progression. They continuously interact with surrounding cells and the extracellular matrix, displaying various behaviors collectively known as hallmarks of cancer. Considering the complexity of the interactions between cells in the tumor microenvironment (TME), mathematical models of intracellular signaling within the multicellular environment in tumors are useful. In this review, we first give an overview of the TME, motivating the need for mathematical modeling, followed by a presentation of salient models of signaling in tumor cells, immune cells, and stromal cells. We posit that these published models provide exactly the foundation needed to build more comprehensive models that represent the multicellular TME and its rich network of intercellular interactions.

Source: Current Opinion in Systems Biology

DOI: 10.1016/j.coisb.2021.05.006

Authors: Min Song, Ding Li, Sahak Z. Makaryan, Stacey D. Finley

Institution: University of Southern California

Language: English

Topic: Mathematical Biology Tumor Growth

Subfield: Modeling and Simulation

Field: Mathematics

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,000