Year: 2021
Type: article
Abstract: The use of combined oral contraceptives has been associated with an increased risk of thromboembolic disease. Current in vitro tests are focusing on one or some sets of multiple factors but are not really pharmacodynamic tests. In this report we present thrombodynamics, which are an elegant in vitro analysis that resembles in vivo coagulation on a prothrombotic surface and gives insight in the spatial dynamics of the formation of a fibrin clot and thrombin generation. The effect of the use of three different types combined oral contraceptives, belonging to either the 2nd or 3rd generation, on the thrombodynamic parameters have been investigated. Data show that fibrin clot formation and thrombin generation are increased after 6 months treatment of combined oral contraceptives. Furthermore, with thrombodynamics it is possible to identify the ‘high hemostatic responders’ including multiple factors, which may have the highest risk to develop thrombogenic effects while using combined oral contraceptives.
Institution: GBS Leiden
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3164906760