Work

A PorX/PorY and σ P Feedforward Regulatory Loop Controls Gene Expression Essential for Porphyromonas gingivalis Virulence

Year: 2021

Type: article

Abstract: The anaerobic bacterium Porphyromonas gingivalis is not only the major etiologic agent for chronic periodontitis, but also prevalent in some common noncommunicable diseases such as cardiovascular disease, Alzheimer's disease, and rheumatoid arthritis. We present genetic, biochemical, and biological results to demonstrate that the PorX/PorY two-component system and sigma factor σ P build a specific regulatory network to coordinately control transcription of the genes encoding the type IX secretion system, and perhaps also other virulence factors.

Source: mSphere

DOI: 10.1128/msphere.00428-21

Authors: Chizhou Jiang, Dezhi Yang, Tangsiyuan Hua, Zichun Hua, Wei Kong, Yixin Shi

Institutions: State Key Laboratory of Pharmaceutical Biotechnology, Arizona State University, Nanjing University

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,500