Application of a Lifestyle-Based Score to Predict Cardiovascular Risk in African Americans: The Jackson Heart Study
Year: 2021
Type: article
Abstract: Cardiovascular disease (CVD) primordial prevention tools applicable to diverse populations are scarce. Our aim was to assess the performance of a lifestyle-based tool to estimate CVD risk in an African American population. The Jackson Heart Study is a prospective cohort including 5306 African American participants in Jackson, Mississippi (2000-2004), with a mean follow up of 12 years. The Healthy Heart Score is a lifestyle-based CVD risk prediction model based on nine components: body mass index (BMI), physical activity, smoking, and a 5-component diet score. Gender-specific beta coefficients from its derivation cohorts were used to assess the performance of the Healthy Heart Score. Model discrimination was assessed using Harrell's C-Index for survival data and time dependent Area Under the Curve. Model calibration was evaluated through calibration plots. A total of 189 CVD events occurred. The Healthy Heart Score showed high-moderate discrimination for CVD events (C-statistic 0.75 [95% CI, 0.71-0.78]) but with little improvement over the age-only model. Both the age-only and Healthy Heart Score models had better performance in participants without diabetes at baseline and showed good calibration. In African Americans, the Healthy Heart Score does not improve prediction of mid-life CVD events beyond what is obtained by age alone.
Source: Journal of Clinical Medicine
DOI: 10.3390/jcm10112252
Institutions: Madrid Institute for Advanced Studies, Harvard University, Hospital Universitario La Paz, Hospital La Paz Institute for Health Research, IMDEA Food, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Universidad Autónoma de Madrid, The Ohio State University, Emory University, University of Mississippi Medical Center, Brigham and Women's Hospital, University of Massachusetts Lowell, The Ohio State University Wexner Medical Center
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,376
Funders: Robert Wood Johnson Foundation, Ministerio de Ciencia, Innovación y Universidades, National Institutes of Health, Instituto de Salud Carlos III, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences, National Institute on Minority Health and Health Disparities
Awards: G112182703, G1216488641, G1303440240, The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve Health, G1474727569, G2192872138, G272281204, G3031759, G3395363768, G361393594, G420412549, G4423964575, G4608159596, The Role of The Renin-Angiotensin-Aldosterone System, ARMC5, and Neprilysin in Glucose Metabolism among African Americans, El “Healthy Heart Score” español: validación, desarrollo y transferencia a un entorno laboral de un modelo de predicción basado en estilos de vida para la prevención primordial de enfermedades cardiovasculares, G531053937, G5992966712, G6089578186, G6366654927, G6731921269, G7226679574, G743178690, G7604803519, G8010329878, G829395128
OpenAlex ID: W3165073937