Work

Genome Scale Analysis Reveals IscR Directly and Indirectly Regulates Virulence Factor Genes in Pathogenic Yersinia

Year: 2021

Type: article

Abstract: encounter during infection, IscR levels increase, leading to modulation of genes involved in iron metabolism, stress resistance, cell envelope remodeling, and subversion of host defenses. These data suggest that IscR senses nutritional immunity to coordinate processes important for bacterial survival within the mammalian host.

Source: mBio

DOI: 10.1128/mbio.00633-21

Authors: David Balderas, Erin Mettert, Hanh N. Lam, Rajdeep Banerjee, Tomas Gverzdys, Pablo Alvarez, Geetha Saarunya, Natasha Tanner, Adam Zoubedi, Yahan Wei, Patricia J. Kiley, Victoria Auerbuch

Institutions: University of California, Santa Cruz, University of Wisconsin–Madison, University of South Carolina

Language: English

Topic: Yersinia bacterium, plague, ectoparasites research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: gold

Estimated APC paid: $3,900

Funders: National Institutes of Health, National Human Genome Research Institute, National Institute of Allergy and Infectious Diseases

Awards: Host iron and Yersinia pathogenesis, UCSC Research Mentoring Internship Program: An Initiative to Increase Diversity and Inclusion in Genomics Research

OpenAlex ID: W3165155683

FWCI: 1.27

Cites: 97

Cited by: 16

Related to: 10