Work

Integration of Systemic and Liver-Directed Therapies for Locally Advanced Hepatocellular Cancer: Harnessing Potential Synergy for New Therapeutic Horizons

Year: 2021

Type: review

Abstract: Treatment options in locally advanced hepatocellular carcinoma (HCC) have evolved considerably over the past few years with the recent approval of multiple systemic therapies and significant advances in locoregional therapy. Given the poor prognosis for patients with unresectable HCC, there is significant interest in rationally designed combination therapies. This article reviews the treatment options available to patients with locally advanced HCC and discusses the rationale, ongoing trials, and future prospects for combining locoregional and systemic therapy in both the definitive and neoadjuvant settings.

Source: Journal of the National Comprehensive Cancer Network

DOI: 10.6004/jnccn.2021.7037

Authors: Eric H. Bent, Eric Wehrenberg-Klee, Eugene J. Koay, Lipika Goyal, Jennifer Y. Wo

Institutions: Harvard University, Massachusetts General Hospital, The University of Texas MD Anderson Cancer Center

Language: English

Topic: Hepatocellular Carcinoma Treatment and Prognosis

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W3165257868