Year: 2021
Type: review
Abstract: Engineered cardiac tissues (ECTs) are 3D physiological models of the heart that are created and studied for their potential role in developing therapies of cardiovascular diseases and testing cardio toxicity of drugs. Recreating the microenvironment of the native myocardium in vitro mainly involves the use of cardiomyocytes. However, ECTs with only cardiomyocytes (CM-only) often perform poorly and are less similar to the native myocardium compared to ECTs constructed from co-culture of cardiomyocytes and nonmyocytes. One important goal of co-culture tissues is to mimic the native heart’s cellular composition, which can result in better tissue function and maturity. In this review, we investigate the role of nonmyocytes in ECTs and discuss the mechanisms behind the contributions of nonmyocytes in enhancement of ECT features.
Authors: Sadek Munawar, Irene C. Turnbull
Institution: Icahn School of Medicine at Mount Sinai
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,950
Awards: Replacement of Small Animal Echocardiographic Instrumentation, G2290040486, Defining the role of non-myocytes to achieve biologically relevant engineered myocardial tissues, Harnessing the Benefits of Adult Stem Cell Exosomes for Enhancing Cardiac Contractile Function, Training in Cardiovascular Physiology and Pharmacology, UCSD Future Faculty of Cardiovascular Sciences (FOCUS)
OpenAlex ID: W3165456283