Whitlockite structures in kidney stones indicate infectious origin: a scanning electron microscopy and Synchrotron Radiation investigation
Year: 2021
Type: article
Abstract: In this contribution dedicated to kidney stones containing Whitlockite (Wk), we addressed three questions, namely, the presence of iron in Wk, the relationship between bacterial imprints and the presence of Wk, and finally the relationship between the crystal size of Wk-bearing stones and infection. The complete dataset indicates that iron is not present in our Wk stoichiometry. We also note the presence of bacterial imprints for kidney stones with a high, but sometimes a low content, of Wk. Finally, we propose FE-SEM as a diagnostic tool for stone patients who have a negative urine culture associated with kidney stones containing less than 20% by weight Wk, a low level of carbonate in apatite, and no struvite. Such a diagnostic tool would represent a significant benefit to the clinician.
Source: Comptes Rendus Chimie
DOI: 10.5802/crchim.80
Institutions: Institut de Chimie Physique, Centre National de la Recherche Scientifique, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Université Paris-Saclay, CEA Paris-Saclay - Etablissement de Saclay, Institut Rayonnement-Matière de Saclay, Laboratoire Léon Brillouin, CEA Paris-Saclay, Synchrotron SOLEIL, Université Paris-Sud, Laboratoire de physique des Solides, Institut de physique du globe de Paris, Université Paris Cité, Seoul National University, Inserm, Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Hôpital Tenon, Vrije Universiteit Brussel, Des Maladies Rénales Rares aux Maladies Fréquentes, Remodelage et Réparation, Interfaces, Confinement, Matériaux et Nanostructures
Language: English
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Awards: Calcium pyrophosphate crystal formation and osteoarthritis: in vitro and in vivo studies, Hydroxyapatites substituées nanocristallisées et leurs interfaces avec les milieux biologiques, Determinants of RAndall’s Plaque Outbreak and urolithiasis epidemic: a multidisciplinary approach., G6702880738, G6800258254
OpenAlex ID: W3165836680