Work

HMGB1 promotes tumor progression and invasion through HMGB1/TNFR1/NF-κB axis in castration-resistant prostate cancer.

Year: 2021

Type: article

Abstract: . Our results indicated that HMGB1 is a critical factor in the development and progression of PCa. Moreover, we found that HMGB1 directly interacts with TNFR1, and TNFR1 overexpression in HMGB1 knockdown cells reversed the effects of HMGB1 knockdown. Importantly, our results suggest that HMGB1 binding to TNFR1 promotes tumor progression by activating the NF-κB signaling pathway in PCa; therefore, the HMGB1/TNFR1/NF-κB signaling pathway could serve as a novel therapeutic target for improving PCa therapy.

Source: PubMed

Authors: Ae Ryang Jung, Ga Eun Kim, Mee Young Kim, U-Syn Ha, Sung-Hoo Hong, Ji Youl Lee, Sae Woong Kim, Yong Hyun Park

Institutions: The Catholic University of Korea Seoul St. Mary's Hospital, Catholic University of Korea

Language: English

Topic: Advanced Glycation End Products research

Subfield: Clinical Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3166225361

FWCI: 2.293

Cites: 32

Cited by: 15

Related to: 10