Correlates of persistent endocrine disrupting chemical mixtures among reproductive-aged Black women
Year: 2020
Type: conference-abstract
Abstract: Background: Polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and persistent pesticides are endocrine-disrupting chemicals (EDCs). Demographic and dietary variables have been associated with EDC exposure, but few studies have examined correlates of EDC mixtures.Methods: We used cross-sectional data from a Detroit-based prospective cohort of Black women aged 23-35 years. At baseline, we measured PCBs, PBDEs, and pesticides in non-fasting plasma samples of 765 women. Socioeconomic, demographic, and dietary data were collected through self-administered questionnaires, interviews, and clinic visits. We conducted a principal component analysis (PCA) to characterize profiles of exposure to mixtures of log-transformed lipid-adjusted chemicals. Three principal components (PCs) explained >75% of the variance. We used multivariable linear regression to estimate mean differences (β) in PC scores for each correlate, controlling for confounders determined a priori.Results: PC-1 accounted for 50.9%, PC-2 for 15.0% and PC-3 for 9.2% of the variance of chemical concentrations. PC-1 explained the most variance for organochlorine pesticides and PCB Wolff Groups 2B and 3 (PCB 99, 138/158, 146, 153, 156, 170, 180, 183, 187, 194, 196/203, 199, hexachlorobenzene, oxychlordane, trans-nonachlor, and 2,2-bis(4-chlorophenyl)-1,1-dichloroethene); PC-2 for brominated flame retardants (PBDE 28, 47, 99, 153 and 209); and PC 3 for Wolff Group 2A plus PCB 28 (PCB 28, 66, 74, 105, and 118). Having been breastfed in infancy was positively associated with PC-1 (β=0.33, 95% CI=-0.14,0.53) and negatively associated with PC-2 (β=-0.13, 95% CI=-0.26,-0.13) and PC-3 (β=-0.12, 95% CI=-0.21,-0.02). Age, smoking, fish and alcohol consumption were positively associated with PC-1, suggesting these factors are related to higher concentrations of PC-1 biomarkers. Other findings included a positive association of BMI with PC-2, and an inverse association of lactation with PC-1 and PC-3.Conclusions: We characterized distinct profiles of EDC mixtures among Black women in our study, which may help to describe exposure pathways and target interventions.
Source: ISEE Conference Abstracts
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W3166368308