Work

Current Challenges in Fecal Microbiota Transplantation for Clostridioides difficile Infection in Children

Year: 2021

Type: article

Study design: Observational Study

Abstract: INTRODUCTION: The impact of the 2019 US Food and Drug Administration safety alert involving transmission of multidrug resistant organisms through fecal microbiota transplantation (FMT), and the COVID-19 pandemic on the use of FMT in children, is unknown. METHODS: A survey of pediatric gastroenterologists performing FMT for Clostridioides difficile infection was conducted. RESULTS: Of 36 respondents, 17 (47%) and 30 (83%) changed their FMT practices related to the US Food and Drug Administration safety alert and COVID-19 pandemic, respectively, with 22 (61%) of programs halted. DISCUSSION: The US Food and Drug Administration safety alert and COVID-19 pandemic have substantially influenced the availability and access of FMT for children.

Source: The American Journal of Gastroenterology

DOI: 10.14309/ajg.0000000000001350

Authors: Maribeth R. Nicholson, Suchitra K. Hourigan, Maire Conrad, Alka Goyal, Kyle Jensen, Judith Kelsen, Melissa Kennedy, Madison Weatherly, Stacy A. Kahn

Institutions: Vanderbilt University Medical Center, Children's Hospital of Philadelphia, Lucile Packard Children's Hospital, Stanford University, University of Utah, Boston Children's Hospital

Language: English

Topic: Clostridium difficile and Clostridium perfringens research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: Identifying Genomic and Microbial Contributions in Early Childhood-Inflammatory Bowel Disease, G576188615, The Vanderbilt Institute for Clinical and Translational Research (VICTR), Immune, Microbial, and Metabolic Factors that Impact Clostridioides difficile and Inflammatory Bowel Disease in Children

OpenAlex ID: W3166492279

FWCI: 0.739

Cites: 9

Cited by: 13

Related to: 10