한국인 공황장애 환자에서 Citalopram 6개월 유지요법의 효과：전향적, 다기관, 개방 연구
Year: 2006
Type: article
Study design: Clinical Trial
Abstract: Objective：The authors examined the efficacy of citalopram, and its effect on the quality of life in patients with\npanic disorder. Method：Seventy three patients who had panic disorder were recruited for this study. They did\nnot have major depression and other axis I diseases. They were scheduled to be examined 4 times (at baseline,\n4, 12 and 24 weeks) and took citalopram for 24 weeks with a flexible dosing schedule. The primary efficacy\nvariables were the response and remission rates (response：HAMA total score decreased by at least 50%\nfrom baseline; remission：HAMA total score ≤7). Other variables included the Hamilton Rating Scale for\nDepression, Panic Disorder Severity Scale (PDSS), Acute Panic Inventory, Clinical Global Impression Scale and\nSheehan Disabilities Scale (SDS). Results：The number of patients who completed 24 weeks of treatment was\n33 (45.2%). Forty patients who were dropped out consisted of 4 patients with symptom improvement and 36\npatients with failure to return. Response/remission rates were 56.2/31.5% in the last-observation-carried-forward\nmethods and 87.9/69.7% in the observed case data. Treatment with citalopram improved anxiety and depressive\nsymptoms during 24 weeks on all efficacy measures. By a completed patient analysis, citalopram also significantly\nimproved the disability scores on SDS. In this study, any serious adverse effects were not observed. Conclusion：Treatment with citalopram was effective and well-tolerated for the patients with panic disorder, and\nalso improved quality of life in the patients.
Language: Korean
Subfield: Experimental and Cognitive Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: green
OpenAlex ID: W3166585959