Year: 2021
Type: article
Study design: Observational Study
Abstract: Spontaneous miscarriage is one of the most common complications of pregnancy. Even though some risk factors are well documented, there is a paucity of risk scoring tools during preconception. In the S-PRESTO cohort study, Asian women attempting to conceive, aged 18-45 years, were recruited. Multivariable logistic regression model coefficients were used to determine risk estimates for age, ethnicity, history of pregnancy loss, body mass index, smoking status, alcohol intake and dietary supplement intake; from these we derived a risk score ranging from 0 to 17. Miscarriage before 16 weeks of gestation, determined clinically or via ultrasound. Among 465 included women, 59 had miscarriages and 406 had pregnancy ≥ 16 weeks of gestation. Higher rates of miscarriage were observed at higher risk scores (5.3% at score ≤ 3, 17.0% at score 4-6, 40.0% at score 7-8 and 46.2% at score ≥ 9). Women with scores ≤ 3 were defined as low-risk level (< 10% miscarriage); scores 4-6 as intermediate-risk level (10% to < 40% miscarriage); scores ≥ 7 as high-risk level (≥ 40% miscarriage). The risk score yielded an area under the receiver-operating-characteristic curve of 0.74 (95% confidence interval 0.67, 0.81; p < 0.001). This novel scoring tool allows women to self-evaluate their miscarriage risk level, which facilitates lifestyle changes to optimize modifiable risk factors in the preconception period and reduces risk of spontaneous miscarriage.
Source: Scientific Reports
Institutions: National University of Singapore, National University Health System, KK Women's and Children's Hospital, Duke-NUS Medical School, Tampere University, University of Tampere, National Health Service, University Hospital Southampton NHS Foundation Trust, MRC Lifecourse Epidemiology Unit, University of Southampton, Agency for Science, Technology and Research, Singapore Institute for Clinical Sciences, National University Hospital, SingHealth Duke-NUS Academic Medical Centre
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,990
Funders: National Institute for Health and Care Research, British Heart Foundation, European Commission, National Research Foundation, Singapore Institute for Clinical Sciences, National Research Foundation Singapore, National University Health System, National Institute for Health Research Southampton Biomedical Research Centre, National Institutes of Health, Medical Research Council, National Medical Research Council, National Institute on Aging, Precursory Research for Embryonic Science and Technology
Awards: G1321528303, Programme 1: Musculoskeletal health in later life, G1659327504, G1727471521, G1917706474, G1956390128, G195975639, G2125390887, G2154835441, G2400945375, G2693923786, G2780654756, G2838213439, Interdisciplinary Research Network on Early Adversity & Later Life Reversibility, G3210728687, G3424013768, NIHR Senior Investigator Award, G3778457340, G3873828540, G389277099, G427574963, NIHR Senior Investigator Award, Programme 3: Early development and risk of adult musculoskeletal disease, G4964355645, G5224105001, G524590474, G5318721926, G5439784885, G5755632036, G606602278, G6206044308, G6408020244, G645171559, G6907919727, G71336211, G7348633402, G7388601084, G740803340, MRC Lifecourse Epidemiology Centre - Core Support, G7485733262, G7633864364, G7643966348, G7671148335, G7865205193, G8346907872, G8385395667, Nutrition, Development and Lifelong Health: Studies in European Populations, G8606453147
OpenAlex ID: W3166725375