Comprehensive echocardiographic evaluation of the right heart in patients with pulmonary vascular diseases: the PVDOMICS experience
Year: 2021
Type: article
Abstract: AIMS: There is a wide spectrum of diseases associated with pulmonary hypertension, pulmonary vascular remodelling, and right ventricular dysfunction. The NIH-sponsored PVDOMICS network seeks to perform comprehensive clinical phenotyping and endophenotyping across these disorders to further evaluate and define pulmonary vascular disease. METHODS AND RESULTS: Echocardiography represents the primary non-invasive method to phenotype cardiac anatomy, function, and haemodynamics in these complex patients. However, comprehensive right heart evaluation requires the use of multiple echocardiographic parameters and optimized techniques to ensure optimal image acquisition. The PVDOMICS echo protocol outlines the best practice approach to echo phenotypic assessment of the right heart/pulmonary artery unit. CONCLUSION: Novel workflow processes, methods for quality control, data for feasibility of measurements, and reproducibility of right heart parameters derived from this study provide a benchmark frame of reference. Lessons learned from this protocol will serve as a best practice guide for echocardiographic image acquisition and analysis across the spectrum of right heart/pulmonary vascular disease.
Authors: Christine L Jellis, Margaret M Park, Aiden Abidov, Barry A Borlaug, Evan L Brittain, Robert Frantz, Paul M Hassoun, Evelyn M Horn, Wael A Jaber, Kim Jiwon, Maria G Karas, Deborah Kwon, Jane A Leopold, Bradley Maron, Stephen C Mathai, Reena Mehra, Franz Rischard, Erika B Rosenzweig, W H Wilson Tang, Rebecca Vanderpool, James D Thomas, the PVDOMICS Study Group
Institutions: Cleveland Clinic, Wayne State University, Mayo Clinic, Vanderbilt University Medical Center, Johns Hopkins University, Weill Cornell Medicine, Brigham and Women's Hospital, VA Boston Healthcare System, University of Arizona, NewYork–Presbyterian Hospital, Columbia University Irving Medical Center, Northwestern University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Pulmonary Vascular Disease Phenomics Program (PVDOMICS) Data Coordinating Center, Hopkins Clinical Center for Pulmonary Vascular Disease Phenomics Program, G4177866839, G512874299, PVDOMICS Defining the Future Fingerprints of Pulmonary Vascular Disease, A molecular phenotype of combined pulmonary hypertension, Phenomic and genomic study to subphenotype Hispanics with pulmonary hypertension
OpenAlex ID: W3167144233