Diagnostic value of amygdala volume on structural magnetic resonance imaging in Alzheimer’s disease
Year: 2021
Type: article
Study design: Observational Study
Abstract: BACKGROUND: The main clinical manifestation of Alzheimer's disease (AD) is memory loss, which can be accompanied by neuropsychiatric symptoms at different stages of the disease. Amygdala is closely related to emotion and memory. AIM: To evaluate the diagnostic value of amygdala on structural magnetic resonance imaging (sMRI) for AD. METHODS: In this study, 22 patients with AD and 26 controls were enrolled. Their amygdala volumes were measured by sMRI and analyzed using an automatic analysis software. RESULTS: The bilateral amygdala volumes of AD patients were significantly lower than those of the controls and were positively correlated with the hippocampal volumes. Receiver operating characteristic curve analyses showed that the sensitivity of the left and right amygdala volumes in diagnosing AD was 80.8% and 88.5%, respectively. Subgroup analyses showed that amygdala atrophy was more serious in AD patients with neuropsychiatric symptoms, which mainly included irritability (22.73%), sleep difficulties (22.73%), apathy (18.18%), and hallucination (13.64%). CONCLUSION: Amygdala volumes measured by sMRI can be used to diagnose AD, and amygdala atrophy is more serious in patients with neuropsychiatric symptoms.
Source: World Journal of Clinical Cases
Authors: De-Wei Wang, Shou-Luan Ding, Xian-Li Bian, Shi-Yue Zhou, Hui Yang, Ping Wang
Institutions: Shandong University, Second Hospital of Shandong University
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W3167299518