No association between frailty index and epigenetic clocks in Italian semi-supercentenarians
Year: 2021
Type: article
Study design: Observational Study
Abstract: Centenarians experience successful ageing, although they still present high heterogeneity in their health status. The frailty index is a biomarker of biological age, able to capture such heterogeneity, even at extreme old age. At the same time, other biomarkers (e.g., epigenetic clocks) may be informative the biological age of the individual and potentially describe the ageing status in centenarians. In this article, we explore the relationship between epigenetic clocks and frailty index in a cohort of Italian centenarians. No association was reported, suggesting that these two approaches may describe different aspects of the same ageing process.
Institutions: Istituto delle Scienze Neurologiche di Bologna, University of Pavia, IRCCS Istituto Auxologico Italiano, University of Florence, Karolinska University Hospital, Karolinska Institutet, Istituto di Genetica Molecolare, University of Bologna, University of Milan, Istituti Clinici Scientifici Maugeri, Nottingham University Hospitals NHS Trust, Queen's Medical Centre, University of Calabria, N. I. Lobachevsky State University of Nizhny Novgorod, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Language: English
Topic: Frailty in Older Adults
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,750
OpenAlex ID: W3167491975