Sex-specific transcriptional differences and loss of gene imprinting in pancreatic neuroendocrine tumors
Year: 2021
Type: preprint
Study design: Observational Study
Abstract: Pancreatic neuroendocrine tumors (PNETs) occur more frequently in men and are associated with higher mortality in males; however, the molecular basis for these sexual dimorphisms is unclear. Here, we demonstrate that PNETs are associated with the emergence of unique sex-specific transcriptomic differences that are not observed in non-neoplastic pancreatic islet tissues. We also show that while widespread sex-specific differences are present in the DNA methylation landscapes of control pancreatic islets, they are erased in PNETs. This includes a loss of imprinting with regards to many genes. These results implicate an emergence of sex-associated genetic and epigenetic dysregulations in PNETs.
Source: medRxiv
Authors: Nikolay A. Ivanov, Kirill Grigorev, Thomas J. Fahey, Brendan M. Finnerty, Christopher E. Mason, Irene M. Min
Institution: Weill Cornell Medicine
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3167827003