Work

Review of Gastrointestinal Motility in Cystic Fibrosis

Year: 2021

Type: review

Abstract: Gastrointestinal manifestations in patients with cystic fibrosis (CF) are extremely common and have recently become a research focus. Gastrointestinal (GI) dysfunction is poorly understood in the CF population, despite many speculations including the role of luminal pH, bacterial overgrowth, and abnormal microbiome. Nevertheless, dysmotility is emerging as a possible key player in CF intestinal symptoms. Our review article aims to explore the sequelae of defective cystic fibrosis transmembrane conductance regulator (CFTR) genes on the GI tract as studied in both animals and humans, describe various presentations of intestinal dysmotility in CF, review newer diagnostic motility techniques including intraluminal manometry, and review the current literature regarding the potential role of dysmotility in CF-related intestinal pathologies.

Source: Journal of Cystic Fibrosis

DOI: 10.1016/j.jcf.2021.05.016

Authors: Sara Henen, Christine Denton, Jeff Teckman, Drucy Borowitz, Dhiren Patel

Institutions: Cardinal Glennon Children’s Medical Center, Saint Louis University, University at Buffalo, State University of New York

Language: English

Topic: Cystic Fibrosis Research Advances

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,700