Ambient ultraviolet radiation and major salivary gland cancer in the United States
Year: 2020
Type: conference-abstract
Abstract: Background: Risk of major salivary gland cancer (SGC) increases dramatically following a diagnosis of skin cancer, suggesting a shared risk factor such as exposure to ultraviolet radiation (UVR). We examined the association between ambient UVR and risk of primary SGC by histological subtype and race/ethnicity using data from the Surveillance, Epidemiology, and End Results (SEER) cancer registry program linked to United States county-level, satellite-based ambient UVR. Methods: A total of 18,168 primary SGC cases were reported from 2000 to 2016 to 16 SEER registries. Satellite-based ambient UVR was derived from the Total Ozone Mapping Spectrometer database. Incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were computed using mixed-effects Poisson regression with adjustment for age, sex, calendar year, and a random effect for cancer registry. Results: Incidence of squamous cell carcinoma of the SGC (SCCSGC) in non-Hispanic whites was significantly higher than incidence in other races/ethnicities. SCCSGC risk was significantly higher for UVR quartile (Q) 4 in all races/ethnicities (Q4 vs Q1 IRR = 1.44; 95% CI = 1.17-1.77), and in non-Hispanic whites (Q4 vs Q1 IRR = 1.47; 95% CI = 1.18-1.82). However, no association with UVR was found for other subtypes or in other races/ethnicities. Discussion: This association between UVR and SCCSGC suggests that a subset of SCCSGC may represent metastases from cutaneous squamous cell carcinoma. If this is confirmed through UV mutational signature analysis, patients with SCCSGC may benefit from skin cancer surveillance to search for an occult primary cutaneous squamous cell carcinoma and to screen for additional skin cancers. Skin cancer patients may also benefit from oral screening for symptoms like dry month and pain to enable early detection of salivary gland metastases.
Source: ISEE Conference Abstracts
Authors: Z. Mai, M. Sargen, R. Pfeiffer, M. Tucker, E. Cahoon
Institution: National Cancer Institute
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W3168289607