RETRACTED: Two Co(II) coordination polymers: Magnetic properties and treatment activity on cochlear ischemia reperfusion injury (CIRI) by reducing the inflammatory response

Year: 2021

Type: article

Abstract: In the current study, under conditions of solvothermal reaction, two coordination polymers (CPs), namelcy, {[Co(TZMB)(1,4-bipb)(H2O)]·H2O}n (1) and {[Co2(TZMB)2(H2O)(DMA)]·DMA}n (2), have been obtained with or without using the pyridine ancillary linker 1,4-bis(pyrid-4-yl)benzene (4-bipb) via utilizing Y-type N-heterocyclic carboxylic acid 4,4′-(1H-1,2,4-triazol-1-yl)methylene-bis(benzoic acid) (H2TZMB). From the magnetic researches, the antiferromagnetic coupling between contiguous metal ions exists in compounds 1 and 2. The treatment effect of compounds 1 and 2 against the cochlear ischemia reperfusion injury (CIRI) was assessed and the related mechanism was explored at the same time. Firstly, the ELISA detection was conducted to determine the influence of the new compounds on the releasing of inflammatory cytokines by the inner ear endothelium. Next, the relative expression levels of genes related with ROS production in the inner ear endothelium was assessed by the real time RT-PCR detection.

Source: Arabian Journal of Chemistry

DOI: 10.1016/j.arabjc.2021.103253

Authors: Fu-Sen Wang, Qing Zhou, Bing Hu, Jiu-Ping Liang, Yue-E Zou

Institutions: Shenzhen University, Shenzhen Second People's Hospital

Language: English

Topic: Metal-Organic Frameworks: Synthesis and Applications

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,250