Work

The association between food insulin index and odds of non-alcoholic fatty liver disease (NAFLD) in adults: a case-control study.

Year: 2021

Type: article

Abstract: AIM: of developing NAFLD in adult Iranians. BACKGROUND: Hyperinsulinemia may play an important role in the development of non-alcoholic fatty liver disease (NAFLD) because of the relationship between insulin response and body fat accumulation. METHODS: A case-control study of 169 NAFLD patients and 200 healthy adults aged 18-55 years was conducted. Dietary data was collected using a validated 168-item quantitative food frequency questionnaire (FFQ). Food insulin index (FII) was calculated by dividing the total insulin load by total energy intake (kcal/day). Total insulin load (ILoverall) was also calculated using a standard formula. RESULTS: for trend <0.001) and obesity (OR=2.33, 95% CI: 0.97-5.75) compared to the lowest tertiles. Potential confounders for the association were controlled. CONCLUSION: This study found that adherence to a diet with high FII was associated with greater odds of NAFLD and overweight or obesity. Additional studies are required to better understand this association.

Source: Gastroenterology and hepatology from bed to bench.

Authors: Somaye Fatahi, Mohammad Hassan Sohouli, Appaji Rayi, Farshad Teymoori, Farzad Shidfar

Institutions: Iran University of Medical Sciences, Charleston Area Medical Center, Research Institute for Endocrine Sciences, Shahid Beheshti University, Shahid Beheshti University of Medical Sciences

Language: English

Topic: Liver Disease Diagnosis and Treatment

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Iran University of Medical Sciences

OpenAlex ID: W3170270826

FWCI: 0.587

Cites: 39

Cited by: 8

Related to: 10