The Associations of Dietary Copper with Incident Dementia: The Atherosclerosis Risks in Community (ARIC) Study
Year: 2020
Type: conference-abstract
Abstract: Background/Aim: Copper may be involved in Alzheimer’s disease pathogenesis. In particular, a combination of high dietary copper intake and high cholesterol may accelerate cognitive decline. We aimed to examine the associations of dietary copper intake in the presence of a high fat diet with incident dementia in a community-dwelling sample in the United States. Methods: The Atherosclerosis Risks in Community (ARIC) Study was used for analysis. Dietary copper (including that from food and dietary supplements) and saturated fat intake were calculated as the average intake across the 1st (1987-1989) and 3rd (1993-1995) visits of the ARIC study, based on information collected from the 61-item Food Frequency Questionnaires. Dementia was ascertained based on in-person assessment, hospital discharge codes, and other supplemental methods throughout follow-up. Participants with diagnosed dementia at study baseline (Visit 4) were excluded from analysis. Cox proportional-hazards models were used to examine the associations of dietary copper (from food, supplements, total) with incident dementia. Potential interactions between dietary copper as continuous variables and high saturated fat intake (defined as the upper 25th percentile) were tested. Results: A total of 9,492 participants (mean age: 62.9±9.7 years, 43.9% male, 17.5% African American) were included in the analysis, with an average follow-up time of 16.3 years. Each 1 mg/day higher intake of total dietary copper (hazard ratio (HR): 1.45, 95% confidence interval (CI): 1.02, 2.06) and copper from food (HR: 1.42, 95% CI: 1.04, 1.94) were associated with higher incident dementia among those with a high intake of saturated fat after covariate adjustment. Intake of copper from supplements was not associated with dementia. Conclusions: The combination of a diet high in both copper and saturated fat may increase the risk of dementia among community-dwelling populations.
Source: ISEE Conference Abstracts
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W3170512619