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[Precision medicine in complex diseases].

Year: 2021
Type: article
Abstract: Complex diseases represent a number of common disorders such as allergic conditions, cardiovascular, metabolic and chronic inflammatory diseases. These diseases are caused by a combination of genetic, environmental and lifestyle factors. This complex etiology creates challenges when it comes to diagnostics, follow-up programs and treatment. Although exact disease mechanisms are yet to be elucidated for most complex diseases, key genetic determinants have been mapped and omics profiling has unraveled involved pathways. Using this wealth of data, precision medicine applications have started to appear also for common, complex diseases. In this article, we review current precision medicine applications from a clinical point of view and outline briefly a roadmap ahead for further clinical implementation of precision medicine in complex diseases.
Source: PubMed
Authors: Erik Melén, Bo Jacobsson, Mikael Benson, Marju Orho-Melander, Jonas Halvarson, Christina Jern
Institutions: Karolinska Institutet, Stockholm South General Hospital, Sachs' Children and Youth Hospital, Sahlgrenska University Hospital, University of Gothenburg, Linköping University, Lund University, Örebro University, Örebro University Hospital
Language: Swedish
Subfield: Genetics
Open Access status: green
OpenAlex ID: W3162144408
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Related to: 10