Work

Homing in on genomic instability as a therapeutic target in cancer

Year: 2021

Type: article

Abstract: While genomic instability is a hallmark of cancer, its genetic vulnerabilities remain poorly understood. Identifying strategies that exploit genomic instability to selectively target cancer cells is a central challenge in cancer biology with major implications for anti-cancer drug development.

Source: Nature Communications

DOI: 10.1038/s41467-021-23965-5

Authors: Craig M. Bielski, Barry S. Taylor

Institutions: Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, Loxo Oncology at Lilly (United States)

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,560