Year: 2021
Type: review
Abstract: Cardiac regenerative medicine faces big challenges such as a lack of adult cardiac stem cells, low turnover of mature cardiomyocytes, and difficulty in therapeutic delivery to the injured heart. The interaction of bioengineering and cardiac regenerative medicine offers innovative solutions to this field. For example, cell reprogramming technology has been applied by both direct and indirect routes to generate patient-specific cardiomyocytes. Various viral and non-viral vectors have been utilized for gene editing to intervene gene expression patterns during the cardiac remodeling process. Cell-derived protein factors, exosomes, and miRNAs have been isolated and delivered through engineered particles to overcome many innate limitations of live cell therapy. Protein decoration, antibody modification, and platelet membranes have been used for targeting and precision medicine. Cardiac patches have been used for transferring therapeutics with better retention and integration. Other technologies such as 3D printing and 3D culture have been used to create replaceable cardiac tissue. In this review, we discuss recent advancements in bioengineering and biotechnologies for cardiac regenerative medicine.
Authors: Mira Chingale, Dashuai Zhu, Ke Cheng, Ke Huang
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,950
Awards: Targeted Anti-IL-1β Platelet Mimetics for Cardiac Detoxification and Repair, Engineer Artificial Exosomes for Treating Myocardial Infarction, Enhancing vascular delivery of stem cells and microparticles, Cardiac Patches Loaded with Stem Cell Factors to Treat Heart Failure, G8003537737, Restoring exosome functions in post-MI hearts by modulating miR-21, Harnessing Platelet-Endothelial Interactions for Exosome Delivery, Developing Long Noncoding RNA Therapy for Precision Cardiac Repair
OpenAlex ID: W3171009206