[Differential expression of miR-30a-5p in post stroke depression and bioinformatics analysis of the possible mechanism].
Year: 2020
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To investigate the differential expression of miR-30a-5p in patients with poststroke depression and explore the possible mechanism. METHODS: =25), and their plasma levels of miR-30a-5p were detected using qPCR. The STARBASE Database ENCORI miRNA-mRNA module and Comparative Toxicogenomics Database were used to predict and screen the possible target genes related to miR-30a-5p, and the possible mechanism of the target genes was further analyzed through bioinformatics. RESULTS: =0.0005) at the cutoff value of 1.597, with a sensitivity and specificity of 0.727 and 0.840, respectively. The target proteins of miR-30a-5p involved a wide range of biological processes, including signal transduction, intercellular communication, regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism. KEGG pathway enrichment analysis showed that the target proteins affected mainly the neural nutrient signaling pathway, axon guidance signaling pathway and insulin signaling system. We also identified the top 20 HUB genes that might be associated with post-stroke depression. CONCLUSIONS: Plasma miR-30a-5p is differentially expressed in PSD and can serve as a new blood marker for diagnosis and also a therapeutic target of PSD.
Source: PubMed
Authors: Jia Hu, Zhiming Zhou, Qian Yang, Ke Yang
Language: Chinese
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3082570258